2022

Lan F, Saba S, Ross TD, Zhou Z, Krauska K, Anantharaman K, Landick R and Venturelli OS. Massively parallel single-cell sequencing of genetic loci in diverse microbial populations. In revision. bioRxiv preprint: doi:10.1101/2022.11.21.517444.

Lan F, Saba J, Qian Y, Ross TD, Landick R and Venturelli OS. Single-cell bacterial sequencing of invertible loci reveals promoter inversion rates as a strong determinant of population heterogeneity. bioRxiv preprint: doi:10.1101/2022.10.31.514637.

Thompson J, Zavala V and Venturelli OS. Integrating a tailored recurrent neural network with Bayesian experimental design to optimize microbial community functions. Submitted. bioRxiv doi:10.1101/2022.11.12.516271.

Juang, DS et al. Microbial community interactions on a chip. Submitted. bioRxiv preprint: doi:10.1101/2022.10.17.51.511674

Hromada S and Venturelli OS. Microbial interactions impact the growth response of Clostridioides difficile to antibiotics. In revision. bioRxiv preprint: doi:10.1101/2022.09.16.508345

Baranwal M, Clark RL, Thompson J, Sun Z, Hero AO and Venturelli OS. Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics. eLife https://doi.org/10.7554/eLife.73870.

Cheng YY, Zhou Z, Papadopoulos JM, Zuke JD, Falbel TG, Anantharaman K, Burton BM and Venturelli OS. Efficient plasmid transfer via natural competence in a synthetic microbial community. Submitted. bioRxiv preprint: doi:10.1101/2020.10.19.342733.

Loss EO, Thompson J, Cheung KP, Qian Y and Venturelli OS. Growth limitation via chemically complex carbohydrates reduces sensitivity of synthetic human gut communities to perturbations. Accepted in Nat Eco Evo. bioRxiv preprint: doi:10.1101/2022.04.08.487701.

Connors BM, Ertmer S, Clark RL, Thompson J, Pfleger BF and Venturelli OS. Model-guided design of the diversity of a synthetic human gut community. In revision. bioRxiv preprint: doi:10.1101/2022.03.14.484355.

Cheng YY, Chen Z, Cao X, Ross TD, Falbel TG, Burton BM and Venturelli OS. Programming bacteria to sense environmental DNA. Submitted. bioRxiv preprint: doi:10.1101/2022.03.10.483875v1.

Feng J, Qian Y, Zhou Z, Ertmer S, Vivas E, Lan F, Hamilton JJ, Rey FE, Anantharaman K and Venturelli OS. Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions. Cell Host & Microbe 30, 1-16.

Li C, Humayun M, Walker GM, Park KY, Connors BM, Feng J, Pellitteri-Hahn MC, Scarlett CO, Li J, Feng Y, Clark RL, Hefti H, Schrope J, Venturelli OS and Beebe DJ. Under-oil autonomously regulated oxygen microenvironments: A Goldilocks principle-based approach for microscale cell culture. Adv. Sci. 2022 2104510.

2021

Hromada S, Qian Y, Jacobson TB, Clark RL, Watson L, Safdar N, Amador-Noguez D and Venturelli OS (2021). Negative interactions determine the growth of C. difficile in synthetic human gut communities. Mol. Syst. Biol. 17:e10355

Clark RL, Connors BM, Stevenson DM, Hromada SE, Hamilton JJ, Amador-Noguez D and Venturelli OS (2021). Design of synthetic human gut microbiome assembly and butyrate production. Nat Commun 12:3254 https://doi.org/10.1038/s41467-021-22938-y.

See Research Highlights in Nat Chem Biol 2021

Leggieri PA, Liu Y, Hayes H, Connors B, Seppala S, O'Malley MA and Venturelli OS (2021). Integrating systems and synthetic biology to understand and engineer microbiomes. Annual Review of Biomedical Engineering. 23:1 doi: 10.1146/annurev-bioeng-082120-022836.

Qian Y, Lan F and Venturelli OS (2021). Towards a deeper understanding of microbial communities: integrating experimental data with dynamic models. Curr. Opin. Microbiol. 12, 84-92.

2020

Gupta S, Ross TD, Gomez MM, Grant JL, Romero PA and Venturelli OS (2020). Investigating the dynamics of microbial consortia in spatially structured environments. Nature Commun. 11, DOI: 10.1038/s41467-020-16200-0.

2019

Lawson, C. E., Harcombe, W. R., Hatzenpichler, R., Lindemann, S. R., Löffler, F. E., O’Malley, M. A., ... & Weissbrodt, D. G. (2019). Common principles and best practices for engineering microbiomes. Nature Reviews Microbiology, 1-17 Common principles and best practices for engineering microbiomes. Nature Reviews Microbiology, 1-17.

Zengler Karsten et al. EcoFABs: advancing microbiome science through standardized fabricated ecosystems. Nature methods 16.7 (2019): 567-571.

Hsu RH, Clark RL, Tan JW, Ahn JC, Gupta G, Romero PA and Venturelli OS. Microbial interaction network inference in microfluidic droplets. Cell Systems 9, 1-14.

Shin S, Venturelli OS and Zavala V. Scalable Nonlinear Programming Framework for Parameter Estimation in Dynamic Biological System Models. PLoS Comp Biol, 15(3), e1006828.

Cao X, Hamilton JJ and Venturelli OS. Understanding and controlling distributed biochemical pathways in microbial communities. Biochemistry 58(2), 94-107.

2018

Venturelli OS, Carr AC, Fisher G, Hsu RH, Lau R, Bowen BP, Hromada S, Northen T and Arkin AP. Deciphering microbial interactions in synthetic human gut microbiome communities. Mol Syst Biol 14, e8425.

See C Abreu et al. News & Views (MSB) and featured on the cover of MSB

2017

Venturelli OS. What Is the Role of Circuit Design in the Advancement of Synthetic Biology? Cell Systems. 4(5) 476-77.

Venturelli OS. Tei M, Bauer S, Chan JGL, Petzold, C and Arkin AP (2017). Programming mRNA decay to modulate synthetic circuit resource allocation. Nat Commun. DOI: 10.1038/ncomms15128

Venturelli OS, Egbert RG and Arkin AP (2016). Towards engineering biological systems in a broader context. J. Mol. Biol. 428(5):928-944

2015

Chevalier M, Venturelli OS and El-Samad H (2015). The impact of different sources of fluctuations on mutual information in biochemical networks. PLoS Comput Biol. 11(10):e1004462.

Venturelli OS, Zuleta I, Murray RM, El-Samad H (2015). Population diversification in a yeast metabolic program promotes anticipation of environmental shifts. PLoS Biol. 13(1):e1002042.

Prior to 2015

Venturelli OS, El-Samad H, Murray RM (2012). Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response. Proc Natl Acad Sci USA. 109(48):E3324-33.

Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD, Brunet A (2011). The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene. 30(29):3207-21

Bloom JD, Lu Z, Chen D, Raval A, Venturelli OS, Arnold FH (2007). Evolution favors protein mutational robustness in sufficiently large populations. BMC Biol. 30(29):3207-21

2020 Gupta S, Ross TD, Gomez MM, Grant JL, Romero PA and Venturelli OS (2020). Investigating the dynamics of microbial consortia in spatially structured environments. Nature Commun. 11, DOI: 10.1038/s41467-020-16200-0.